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. 2023 Mar 1;66(6):3664–3702. doi: 10.1021/acs.jmedchem.2c01229

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© 2023 The Authors. Published by American Chemical Society

Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/).

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Structure of RdRp (nsp12–nsp7–nsp8 complex) bound to the template-primer RNA and the triphosphate form of remdesivir (PDB ID 7BV2(189)). The identified mutations on nsp12, connected with resistance to GS-441524, are highlighted. Nsp12 is shown in a light cyan cartoon; target residues and remdesivir are in sticks (cyan and orange carbons, respectively). Nsp7 and nsp8 are shown in gold and purple cartoons, respectively, surrounded by their surfaces. The template-primer RNA is shown in dark red, and magnesium ions are displayed as green spheres (arbitrary radius).