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. 2023 Mar 1;66(6):3664–3702. doi: 10.1021/acs.jmedchem.2c01229

Figure 6.

Figure 6

Details of the X-ray crystallographic complexes SARS-CoV-2 Mpro: inhibitors in the same binding site framework. (A) 13b (dark violet carbons) in complex with SARS-CoV-2 Mpro (lilac, PDB ID 6Y2F(6)). (B) 18p (green carbons) in complex with EV71 3Cpro (light green, PDB ID 7DNC(38)). (C) 5h (cyan carbons) in complex with SARS-CoV-1 Mpro (light green, PDB ID 1WOF(8)). (D) PF-00835231 (purple carbons) in complex with SARS-CoV-2 Mpro (lilac, PDB ID 6XHM(42)). (E) PF-07321332 (dark pink carbons) in complex with SARS-CoV-2 Mpro (lilac, PDB ID 7VH8(46)). (F) 15l (dark purple carbons) in complex with SARS-CoV-2 Mpro (lilac, PDB ID 7MBI(47)). (G) 11a (violet carbons) in complex with SARS-CoV-2 Mpro (lilac, PDB ID 6LZE(22)). (H) MI-23 (magenta carbons) in complex with SARS-CoV-2 Mpro (lilac, PDB ID 7D3I(48)). The protein is shown in a cartoon; the ligand and the residues lining the pocket are shown in capped sticks. The color scheme is red for oxygen, blue for nitrogen, yellow for sulfur, and gray for halogens.