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. 2023 Mar 1;66(6):3664–3702. doi: 10.1021/acs.jmedchem.2c01229

Figure 8.

Figure 8

Active site views of the structures of (A, B) SARS-CoV-1 Mpro (cyan) in complex with (A) ML188 (pink carbons, PDB ID 3V3M(55)) and (B) SID24808289 (black carbons, PDB ID 4MDS(61)) and (C) SARS-CoV-2 Mpro (lilac) in complex with S-217622 (firebrick carbons, PDB ID 7VU6(78)). The protein is shown in a cartoon; the ligand and the residues lining the pocket are shown in capped sticks. Oxygen atoms are colored red, nitrogen atoms are blue, sulfur atoms are yellow, and halogen atoms are gray.