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. 2023 Mar 11;29(5):343–353. doi: 10.1016/j.molmed.2023.02.004

Table 1.

Therapy of preclinical models of neural disease with Trojan horse LNPs

Neural disease Therapeutic target Promoter Refs
PD TH GFAP [68]
GDNF TH [69]
Brain cancer EGFR antisense RNA SV40 [70]
EGFR shRNA (RNAi) U6 [71]
NPC1 NPC1 PDGF-B [7]