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. 2023 Mar 11;8:36. doi: 10.1038/s41541-023-00630-0

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Curves shown are for D57 (a) anti-spike IgG concentration or (b) pseudovirus (PsV)-nAb ID50 titer. The dotted black lines indicate bootstrap pointwise 95% confidence intervals. The green histogram is an estimate of the density of D57 antibody marker level and the horizontal gray line is the overall vaccine efficacy from 7 to 92 days post D35, with the dotted gray lines indicating the 95% confidence intervals. Analyses adjusted for age and baseline risk score. Curves are plotted over the antibody marker range from the 2.5th percentile to the 97.5th percentile: 21.3 to 1088 BAU/ml for anti-spike IgG and 1.31 to 270 IU50/ml for PsV-nAb ID50.