Table 2.
Hazard ratios of COVID-19 (A) per 10-fold increase or (B) per standard deviation increase in each D57 marker in baseline negative vaccine recipients.
| A | |||||
|---|---|---|---|---|---|
| D57 Antibody Marker | Hazard Ratio per 10-fold Increase | P-value* (2-sided) | Q-value** | FWER** | |
| Point Est. | 95% CI | ||||
| Anti Spike IgG (BAU/ml) | 0.32 | (0.14, 0.76) | 0.009 | 0.017 | 0.015 |
| PsV-nAb ID50 (IU50/ml) | 0.28 | (0.10, 0.77) | 0.013 | 0.019 | 0.016 |
| B | |||||
|---|---|---|---|---|---|
| D57 Antibody Marker | Hazard Ratio per Standard Deviation-Increment Increase | ||||
| Point Est. | 95% CI | ||||
| Anti Spike IgG (BAU/ml) | 0.57 | (0.37, 0.87) | |||
| PsV-nAb ID50 (IU50/ml) | 0.48 | (0.27, 0.86) | |||
Analyses were adjusted for age and baseline risk score. Maximum failure event 92 days post Day 57 visit.
*P-values are not shown for B because they are structurally identical to those for A.
**Q-value and FWER (family-wise error rate) are computed over the two p-values for the two quantitative markers using the Westfall and Young permutation method (10,000 replicates).