Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Jan 12;28(3):993–1003. doi: 10.1038/s41380-022-01913-z

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 1 — X axis: The environmental complexity during behavioral monitoring ranges from a standard and highly controlled setups (e.g., an empty box) to natural. Y axis: The duration of behavioral monitoring can last from a few minutes (e.g., 10 min in the 3 chamber social interaction tests) to days or even weeks. Rodents that are kept for prolonged time in a given setup, can either be tracked continually or data can be sampled based on timepoints of interest. Z axis: The complexity of the detected behavioral readouts ranges from simple and artificial (e.g., interaction through a mesh with a restricted conspecific) to complex and more ethologically relevant behaviors (e.g., attacks and chases). Various behavioral paradigms can be qualitatively positioned in this three-dimensional space. The relative advantages and drawbacks of the different paradigms/approaches in terms of reproducibly, accuracy and cost effectiveness are discussed in the text. (RI- Resident Intruder Test, HCM- Home Cage Monitoring, VBS- Visible Burrow System, SB- Social Box).