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. 2022 Nov 15;28(3):1170–1181. doi: 10.1038/s41380-022-01865-4

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Isolated active mitochondria derived from either healthy controls (HC) or SZ patients were transplanted into HC- and SZ-hLCLs and their O₂ consumption, as well as its inhibition by DA, were measured by Clark oxygen electrode five days after delivery. a Significant differences in basal O₂ consumption between the six experimental groups (F(5,34) = 7.67, P < 0.0001). Reduced respiration of SZ-hLCLs (SZ vs. HC, P < 0.0003) was restored to normal levels after transplantation with mitochondria derived from HC (SZ vs. SZ + HC-Mit, P < 0.0085; HC vs. SZ + HC-Mit, P > 0.05) but remained impaired after transplantation with mitochondria isolated from SZ-hLCLs (SZ vs. SZ + SZ-Mit, P > 0.05; HC vs. SZ + SZ-Mit, P < 0.0012;). Mitochondria transplantation into HC-hLCLs impaired basal respiration regardless of mitochondria origin (HC vs. HC + HC-Mit, P < 0.0071; HC vs. HC + SZ-Mit, P < 0.0025). b One-way ANOVA shows significant differences in DA inhibition of O₂ consumption between groups (F(5,36) = 15.9, P < 0.0001). Inhibition of O₂ consumption by DA was increased in SZ-hLCLs as compared to HC-hLCLs (HC vs. SZ, P < 0.0001) and was attenuated to normal levels by transplanted HC-mitochondria (SZ vs. SZ + HC-Mit, P < 0.049; SZ + HC-Mit, vs. HC P > 0.05) but not by SZ-mitochondria (HC vs. SZ + SZ-Mit, P < 0.0001; SZ vs. SZ + SZ-Mit, P > 0.05). SZ-mitochondria severely increased DA inhibition in HC-hLCLs (HC vs. HC+SZ-Mit, P < 0.0001), while HC-mitochondria had no effect on DA induced inhibition of O₂ consumption (HC vs. HC + HC-Mit, P > 0.05). N = 4–11 cell lines/group, measured in triplicates. All values are means ± s.e.m. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0005.