Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Jan 16;28(3):1090–1100. doi: 10.1038/s41380-022-01922-y

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 1 — A–D Data representative for the chronic pain model (CFA). A Withdrawal threshold of hind paw in response to von Frey hair stimulation under chronic inflammatory pain. B Open field test (OFT). (Top) Representative locomotion traces. (Bottom, left) Distance traversed. (Bottom, middle) percentage of time spent in the central zone. (Bottom, right) Correlation between withdrawal threshold and time spent in the central zone. C Elevated plus maze (EPM) test. (Top) Representative exploration traces. (Bottom, left) Entries made into arms. (Bottom middle) percentage of time in spent in open arms. (Bottom, right) Correlation between withdrawal threshold and time spent in EPM open arms. D (Left) c-Fos expression levels in LS are elevated in CFA over those in the control. Scale bar, 100 μm. E–H Data representative for the anxiety model (CRS) shown similarly to (A–D). *P < 0.05, **P < 0.01, ***P < 0.001. ns, no significant difference (P > 0.05). Data are presented as the means ± SEM. For further details of statistical data analysis see Table S1.