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. 2022 Oct 29;159(3):275–292. doi: 10.1007/s00418-022-02156-3

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Fig. 4 — Visualization of sulphated glycosaminoglycans in the different scaffold variants explanted after 3 months in vivo. AB stain to visualize sulphated glycosaminoglycans (sGAGs) of the tissue within the scaffold variants without cells (-cells, a1–a4) and with lapine anterior cruciate ligament (LACL)-derived ligamentocytes, cultured for 1 week on the scaffold in vitro before implantation into nude mice for 12 weeks (a5–a8), control (co, a1, a5), functionalization by gas-phase fluorination (F, a2, a6), collagen foam cross-linked with hexamethylene diisocyanate (HMDI) (coll, a3, a7) and F + coll (a4, a8). AB-stained native LACL (a9). b Results of AB scoring. c sGAG content measured by dimethyl methylene blue (DMMB) assay. -: implanted without cells, + : implanted with LACL-derived ligamentocytes. Kruskal–Wallis test was used for analyses followed by Dunn's post hoc test. p values: * < 0.05. Scale bars 100 µm (a1–a9)