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Comparison of PPARγ variants in regulating prostate cancer signalling and development.
| Prostate epithelial characteristics | PPARγ1 | PPARγ2 |
|---|---|---|
| Lipogenisis (FASN, ACACA) | ↓ | ↓ |
| Fatty acid metabolism (SCD1) | ↓ | ↑ |
| Differentiation | Luminal | Basal |
| Histology | Adenocarcinoma | Benign |
| AR signalling | ↓ | ↑ |
PPARγ1 and PPARγ2 peroxisome proliferator-activated receptor gamma variants 1 and 2, FASN fatty acid synthase, ACACA acetyl-CoA carboxylase alpha, SCD1 stearoyl-CoA desaturase 1.
