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. 2023 Jan 2;13(3):1887–1898. doi: 10.21037/qims-22-271

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2023 Quantitative Imaging in Medicine and Surgery. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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Scatter plots showing the correlation between IVIM-DWI parameters and VEGF (A), MMP-2 (B), and MMP-9 (C) expression in HCC. The ADC, D, and D* value unit is ×10^–3 mm²/s, and the f value unit is %. *, indicates P<0.05; **, indicates P<0.01; ***, indicates P<0.001. D, slow apparent diffusion coefficient; D*, fast apparent diffusion coefficient; f, fast apparent diffusion coefficient fraction. IVIM-DWI, intravoxel incoherent motion diffusion-weighted imaging; VEGF, vascular endothelial growth factor; MMP, matrix metalloproteinase; HCC, hepatocellular carcinoma; ADC, apparent diffusion coefficient.