Table 1. Demographic and pulmonary function characteristics of patients who underwent functional assessments.
| Characteristics | Total patients (n=123) | Patients with functional stability (n=84) | Patients with functional worsening (n=39) | P value |
|---|---|---|---|---|
| Median age (years)* | 62 (59 to 68) | 62 (59 to 68) | 63 (56 to 68) | 0.854 |
| Male, n (%) | 107 (87.0) | 75 (89.3) | 32 (82.1) | 0.267 |
| BMI (kg/m2) | 24.6 (23.4 to 26.3) | 25.4 (23.6 to 28.4) | 24.0 (22.6 to 24.9) | 0.002 |
| Median baseline pulmonary function test results* | ||||
| VC% | 85.4 (74.2 to 93.5) | 85.6 (72.0 to 94.0) | 80.5 (74.9 to 90.8) | 0.802 |
| TLC% | 70.0 (62.2 to 79.5) | 72.3 (59.7 to 79.7) | 66.9 (63.7 to 77.9) | 0.839 |
| FVC% | 87.1 (74.5 to 97.2) | 86.7 (74.1 to 97.7) | 89.8 (74.9 to 93.6) | 0.673 |
| DLco% | 56.2 (46.4 to 68.6) | 56.2 (46.2 to 67.8) | 57.5 (46.4 to 69.3) | 0.406 |
| Median time intervals between baseline and follow-up CT (months)* | 10.0 (4.6 to 24.3) | 8.2 (3.8 to 20.2) | 20.6 (8.3 to 24.8) | 0.004 |
| Median changes of pulmonary function test results* | ||||
| VC% | −4.6 (−8.2 to 2.1) | −2.3 (−5.1 to 2.7) | −13.5 (−25.6 to −12.3) | <0.001 |
| TLC% | −1.2 (−5.2 to 3.8) | 2.0 (−2.1 to 7.6) | −8.8 (−17.9 to −4.3) | <0.001 |
| FVC% | −5.0 (−11.8 to 2.4) | −2.4 (−5.3 to 3.1) | −20.0 (−25.1 to −11.9) | <0.001 |
| DLco% | −4.4 (−13.9 to 2.5) | 0.7 (−4.6 to 6.4) | −18.6 (−22.5 to −13.9) | <0.001 |
*, numbers in parentheses represent the interquartile range. BMI, body mass index; VC%, percentage of predicted vital capacity; TLC%, percentage of predicted total lung capacity; FVC%, percentage of predicted forced vital capacity; DLco%, percentage of predicted diffusing lung capacity for carbon monoxide.