Table 1.
Patient demographic and tumour clinicopathologic characteristics.
| mDLC (N = 409) | ILC (N = 1562) | p value | IDC (N = 12,842) | p value | |
|---|---|---|---|---|---|
| BMI (kg/m2) | 26.73 (23.63, 31.13) | 26.99 (23.61, 31.82) | 0.54 | 26.91 (23.29, 31.56) | 0.98 |
| Unknown/missing | 35 | 138 | 1313 | ||
| Tumour size (mm) | 19 (12, 27.75) | 20 (12, 35) | 0.036 | 16 (10, 25) | <0.001 |
| Unknown/missing | 55 | 213 | 1388 | ||
| Age at diagnosis (years) | 59 (49, 68) | 61 (51, 70) | 0.006 | 57 (48, 67) | 0.014 |
| Menopausal status | |||||
| Pre/perimenopausal | 123 (32%) | 381 (26%) | 0.028 | 3914 (33%) | 0.69 |
| Postmenopausal | 266 (68%) | 1091 (74%) | 8050 (67%) | ||
| Unknown/missing | 20 | 90 | 878 | ||
| Race | |||||
| White | 386 (95%) | 1476 (95%) | 0.97 | 11,957 (93%) | 0.59 |
| Black | 18 (4%) | 69 (4%) | 713 (6%) | ||
| Other | 5 (1%) | 17 (1%) | 172 (1%) | ||
| ER | |||||
| Positive | 372 (92%) | 1455 (96%) | <0.001 | 9579 (78%) | <0.001 |
| Negative | 32 (8%) | 56 (4%) | 2779 (22%) | ||
| Unknown/missing | 5 | 51 | 484 | ||
| PR | |||||
| Positive | 339 (84%) | 1229 (82%) | 0.36 | 8530 (70%) | <0.001 |
| Negative | 63 (16%) | 266 (18%) | 3736 (30%) | ||
| Unknown/missing | 7 | 67 | 576 | ||
| HER2 | |||||
| Positive | 11 (8%) | 43 (6%) | 0.49 | 814 (15%) | 0.04 |
| Negative | 126 (89%) | 711 (92%) | 4316 (81%) | ||
| Equivocal | 4 (3%) | 16 (2%) | 190 (4%) | ||
| Unknown/missing | 268 | 792 | 7522 | ||
| Stage (pathologic) | |||||
| I | 157 (42%) | 601 (44%) | 0.053 | 6245 (57%) | <0.001 |
| II | 167 (45%) | 527 (38%) | 3727 (34%) | ||
| III | 42 (11%) | 215 (16%) | 812 (7%) | ||
| IV | 5 (2%) | 27 (2%) | 151 (2%) | ||
| Unknown/missing | 38 | 192 | 1907 | ||
| Grade | |||||
| 1 | 45 (12%) | 192 (16%) | <0.001 | 1634 (15%) | <0.001 |
| 2 | 263 (70%) | 937 (74%) | 5394 (47%) | ||
| 3 | 66 (18%) | 130 (10%) | 4380 (38%) | ||
| Unknown/missing | 35 | 303 | 1434 | ||
| Oncotype Dx RS | |||||
| Low risk (0–17) | 46 (65%) | 226 (67%) | 0.79 | 1105 (61%) | 0.13 |
| Intermediate risk (18–30) | 20 (29%) | 86 (26%) | 457 (25%) | ||
| High risk (>30) | 4 (6%) | 25 (7%) | 257 (14%) | ||
| Unknown/missing | 339 | 1225 | 11,023 | ||
| Lymphovascular invasion | |||||
| Yes | 55 (0.19) | 125 (0.14) | 0.056 | 2074 (0.25) | 0.02 |
| No | 239 (0.81) | 775 (0.86) | 6271 (0.75) | ||
| Unknown/missing | 116 | 669 | 4634 | ||
Median (interquartile) is shown for BMI, tumour size and age at diagnosis, and frequency (%) is shown for all remaining categorical characteristics.