Fig. 7.

Sequence alignment of the P domain of GII.6 with other GII strains based on the secondary structure. P domains of GII.6 were aligned with GII.3 TV24, GII.4 TCH05, GII.10 VN026 and GII.17 KW308. Identical residues are black characters, while similar residues are shown in red characters. The conserved amino acid residues forming the conventional GII-HBGA binding interface are indicated by blue stars. The seven surface loops that constitute the HBGA-binding interface are indicated by blue typeface. The letters in black indicate the identical amino acid sequences, while the red letters indicate the similar amino acids among the five NoVs. Blue boxes frame both identical and similar residues.