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. 2023 Mar 10;14:1323. doi: 10.1038/s41467-023-37094-8

Fig. 8. Proposed model for regulation of senescence by the PHGDH-PKM2-H3pT11 axis.

Fig. 8

PHGDH interacts with PKM2, which prevents PCAF-catalyzed PKM2 K305 and subsequent degradation by autophagy. PHGDH also enhances p300-catalyzed PKM2 K433 acetylation and promotes PKM2 nuclear translocation. PHGDH, together with PSAT1 and PSPH, provides the local serine to stimulate the activity of PKM2 to phosphorylate H3T11 and regulate the expression of senescence-associated genes. For simplicity, the multimerization status of proteins was not displayed in the cartoon.