Figure 2.

Study design and protocol. Legend: Instrumentation corresponds to anesthesia, establishing invasive monitoring and ECMO cannulation which took approximately 3 to 4 h. CS corresponds to the induction of cardiogenic shock by repeated injection of 96% ethanol in the LV. ARF corresponds to the induction of hypoxemia. Therefore, T₀ is the time where differential hypoxemia (CS + ARF) criteria were met. T₁ to T₅ correspond to the study period, during which each group received either a low flow (2.5 L min⁻¹) where brain is perfused entirely by the native heart and lungs, or a high flow (4.5 L min⁻¹) where brain is partially perfused by the ECMO. ARF = acute respiratory failure, CS = cardiogenic shock, ECMO = extracorporeal membrane oxygenation, LV = left ventricle.