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. 2023 Mar 10;13:4002. doi: 10.1038/s41598-023-30226-6

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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cerebral microdialysis values at different timepoints for each study group. Legend: Concentrations of (A) glucose (mmol L⁻¹), (B) lactate (mmol L⁻¹), and (C) pyruvate (mmol L⁻¹), and (D) lactate-pyruvate ratio (LPR). Red lines represent results from the “high flow” group and blue lines from the “low flow” group. Dotted lines represent pathological thresholds as defined by the 2014 Consensus statement from International Microdialysis Forum⁸.