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. 2023 Mar 10;40(4):115. doi: 10.1007/s12032-023-01960-8

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — RNA-seq analysis of RUNX2 k/in and control myeloma cells. Differential expression was analyzed between RUNX2 k/5TGM1 and control 5TGM1 cells by RNA-seq. A Volcano plot of differentially expressed genes. B–D Enriched KEGG and GO terms according to GSEA. E Expression of genes that possibly function in osteoclast promotion or osteoblast suppression. F Protein‒protein interaction (PPI) analysis of RUNX2 from the RNA-seq results. G Expression of LCN2 and M-CSF as confirmed by qPCR