Analysis of α-II-spectrin breakdown products (SBDPs) in the hippocampus. a) Representative Western blot of α-II-spectrin breakdown products (SBDPs) ipsi- (b,c) and contralateral (d,e) hippocampus for male and female mice at 1 and 3 d post-injury. Quantification of 145 kDa SBDP (proportional to necrosis) (b,d) and 120 kDa SBDP (proportional to apoptosis) (c,e) normalized to control mice, respectively. Data are shown as mean ± SD with n = 3 for each treatment group. ns indicates an insignificant different between treatment group. * and ** indicate a significant different with p < 0.05 and p < 0.01, respectively, as determined by one-way ANOVA and Tukey’s post hoc test.