Fig. 2.

Importance plots of the top 20 proteins associated with interstitial (a) and replacement (b) fibrosis. In the analysis of interstitial fibrosis, only three of the 20 proteins were found to be statistically significant predictors of disease after accounting for demographics and traditional cardiovascular disease risk factors (see statistical methods for variables). These proteins include plasminogen activator inhibitor (PAI), insulin-like growth factor binding protein 1 (IGFBP-1), and N-terminal pro-B-type natriuretic peptide (NT-proBNP). Similar to the volcano plot analysis, no proteins were determined to be of statistical importance when accounting for demographics and cardiovascular disease risk factors with replacement fibrosis.