Fig. 3.

Hierarchical clustering results of protein groupings for interstitial fibrosis for those without (a, ECVq1) and with (b, ECVq4) interstitial fibrosis. The clusters for interstitial fibrosis included proteins that were also found to be statistically significant in the volcano plot analysis noted with a red asterisk and 3 proteins that remained statistically significant using Bayesian additive regression tree noted with a blue asterisk. A total of 5 clusters were created for ECVq1 and shown as the color bar at the bottom of Fig. 3a. Redistribution of the 5 clusters for ECVq4 are shown in the color bar at the bottom of Fig. 3b. In the Sankey plot (c), the same cluster color scheme is used and a shift or absence of a shift in proteins to different clusters is qualitatively shown between those with and without interstitial fibrosis.