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. 2023 Feb 16;28:249–263. doi: 10.1016/j.omto.2023.02.004

Figure 8.

Figure 8

Co-delivery of EGFRvIII-DBTE and HER2-DBTE in heterogeneous GBM challenge

(A) A scheme of heterogeneous orthotopic GBM challenge in NSG mice wherein a mixture of U87vIII cells and U251 cells were inoculated in the brain. (B–E) Tumor burden of the challenged mice that received a treatment of (B) pVAX1, (C) EGFRvIII-DBTE, (D) HER2-DBTE, or (E) both EGFRvIII-DBTE and HER2-DBTE. (F) Survival of the challenged NSG mice. (G) IVIS images of the challenged mice. (H) Representative confocal images of the brain sections of the challenged mice at the endpoints of the study. EGFRvIII expression is shown in magenta. HER2 expression is shown in cyan. Nuclei are shown in yellow.