Table 7.
Target interference.
| Sample | LAG-3 Conc (ng/mL) | Screening assay |
Confirmatory assay |
||
|---|---|---|---|---|---|
| Mean OD | SNR | Mean OD | Inhibition (%) | ||
| HPC-LAG3-1 | 640.0 | 0.8093 | 10.69 | 0.0942 | 88.36 |
| HPC-LAG3-2 | 320.0 | 0.802 | 10.59 | 0.0935 | 88.34 |
| HPC-LAG3-3 | 160.0 | 0.7904 | 10.44 | 0.091 | 88.49 |
| HPC-LAG3-4 | 80.0 | 0.7647 | 10.1 | 0.0897 | 88.27 |
| HPC-LAG3-5 | 40.0 | 0.7488 | 9.89 | 0.0914 | 87.79 |
| HPC-LAG3-6 | 20.0 | 0.7822 | 10.33 | 0.0929 | 88.12 |
| HPC-LAG3-7 |
0.0 |
0.7618 |
10.06 |
0.0901 |
88.17 |
| LPC-LAG3-1 | 640.0 | 0.1546 | 2.05 | 0.077 | 50.19 |
| LPC-LAG3-2 | 320.0 | 0.1354 | 1.8 | 0.0759 | 43.94 |
| LPC-LAG3-3 | 160.0 | 0.124 | 1.65 | 0.0726 | 41.45 |
| LPC-LAG3-4 | 80.0 | 0.1234 | 1.64 | 0.0727 | 41.09 |
| LPC-LAG3-5 | 40.0 | 0.1216 | 1.61 | 0.0723 | 40.54 |
| LPC-LAG3-6 | 20.0 | 0.1211 | 1.61 | 0.0726 | 40.05 |
| LPC-LAG3-7 |
0.0 |
0.3781 |
5.02 |
0.0758 |
79.95 |
| NC-LAG3-1 | 640.0 | 0.1085 | 1.44 | 0.0764 | 29.59 |
| NC-LAG3-2 | 320.0 | 0.0916 | 1.22 | 0.0763 | 16.7 |
| NC-LAG3-3 | 160.0 | 0.082 | 1.09 | 0.0729 | 11.1 |
| NC-LAG3-4 | 80.0 | 0.0769 | 1.02 | 0.073 | 5.07 |
| NC-LAG3-5 | 40.0 | 0.0757 | 1.01 | 0.072 | 4.89 |
| NC-LAG3-6 | 20.0 | 0.0761 | 1.01 | 0.0781 | −2.63 |
| NC-LAG3-7 | 0.0 | 0.0734 | 0.97 | 0.081 | −10.35 |
| HLX26 ADA (ng/mL) | Screening assay |
Confirmatory assay |
||||||
|---|---|---|---|---|---|---|---|---|
| LAG-3 (ng/mL) | SNR | Interference (ng/mL) | LAG-3 (ng/mL) | Inhibition (%) | Interference (ng/mL) | |||
| 0.0 rowhead | 160.0 | 80.0 | 1.09 | 74.0 | 320.0 | 160.0 | 16.7 | 102.0 |
| 80.0 | 40.0 | 1.02 | 160.0 | 80.0 | 11.1 | |||