Table 1.
Nine groups of miRNAs and their predicted significant pathways. P < 10-6 indicates statistical significance. Group 10 is the control to negative actions.
| miRNA Groups | Predicted Enriched Pathways | P values | |
|---|---|---|---|
| 1 | 29 | Collagen chain trimerization | 5.50E-18 |
| Collagen biosynthesis and modifying enzymes | 6.20E-16 | ||
| Integrins in angiogenesis | 2.75E-14 | ||
| β1 integrin cell surface interactions | 4.28E-14 | ||
| ECM organization | 1.12E-13 | ||
| miRNA targets in ECM and membrane receptors | 7.61E-08 | ||
| Binding and uptake of ligands by scavenger receptors | 3.21E-06 | ||
| 2 | 29 + 107 + 155 | Collagen chain trimerization | 6.42E-13 |
| Integrins in angiogenesis | 9.52E-13 | ||
| Collagen biosynthesis and modifying enzymes | 6.50E-11 | ||
| Syndecan-1-mediated signalling events | 8.10E-10 | ||
| β1 integrin cell surface interactions | 1.23E-09 | ||
| ECM organization | 2.52E-07 | ||
| Focal adhesion-PI3K-Akt-mTOR-signalling pathway | 3.42E-07 | ||
| 3 | 29 + 107 + 155 + 381 | Integrins in angiogenesis | 5.55E-13 |
| Collagen chain trimerization | 7.81E-12 | ||
| Collagen biosynthesis and modifying enzymes | 7.55E-10 | ||
| Syndecan-1-mediated signalling events | 5.79E-09 | ||
| β1 integrin cell surface interactions | 1.10E-08 | ||
| Focal adhesion-PI3K-Akt-mTOR-signalling pathway | 1.03E-06 | ||
| ECM organization | 4.30E-06 | ||
| Signalling regulating pluripotency of stem cells | 6.82E-06 | ||
| 4 | 29 + 107 + 155 + 543 | Integrins in angiogenesis | 1.55E-12 |
| Collagen chain trimerization | 1.83E-11 | ||
| Syndecan-1-mediated signalling events | 4.32E-10 | ||
| Collagen biosynthesis and modifying enzymes | 1.74E-09 | ||
| β1 integrin cell surface interactions | 2.32E-08 | ||
| Mesodermal commitment pathway | 5.13E-07 | ||
| Focal Adhesion-PI3K-Akt-mTOR-signalling pathway | 5.19E-07 | ||
| ECM organization | 2.09E-06 | ||
| 5 | 29 + 381 | Collagen chain trimerization | 4.20E-15 |
| Integrins in angiogenesis | 2.02E-13 | ||
| Collagen biosynthesis and modifying enzymes | 4.53E-13 | ||
| β1 integrin cell surface interactions | 1.48E-11 | ||
| Syndecan-1-mediated signalling events | 1.57E-11 | ||
| ECM organization | 5.88E-10 | ||
| Focal Adhesion-PI3K-Akt-mTOR-signalling pathway | 8.17E-10 | ||
| miRNA targets in ECM and membrane receptors | 1.64E-06 | ||
| 6 | 29 + 543 | Collagen chain trimerization | 2.51E-14 |
| Integrins in angiogenesis | 1.19E-12 | ||
| Syndecan-1-mediated signalling events | 1.20E-12 | ||
| Collagen biosynthesis and modifying enzymes | 2.65E-12 | ||
| β1 integrin cell surface interactions | 7.12E-11 | ||
| ECM organization | 4.81E-10 | ||
| Focal adhesion-PI3K-Akt-mTOR-signalling pathway | 6.84E-10 | ||
| TET1,2,3 and TDG demethylate DNA | 6.14E-07 | ||
| Senescence and autophagy in cancer | 1.65E-06 | ||
| Protein alkylation leading to liver fibrosis | 7.22E-06 | ||
| 7 | 29 + 155 | Integrins in angiogenesis | 8.04E-15 |
| Collagen chain trimerization | 8.36E-15 | ||
| Collagen biosynthesis and modifying enzymes | 8.95E-13 | ||
| Syndecan-1-mediated signalling events | 2.69E-11 | ||
| β1 integrin cell surface interactions | 2.71E-11 | ||
| ECM organization | 1.38E-09 | ||
| Focal adhesion-PI3K-Akt-mTOR-signalling pathway | 1.91E-09 | ||
| miRNA targets in ECM and membrane receptors | 2.26E-06 | ||
| 8 | 29 + 155 + 381 + 543 | Integrins in angiogenesis | 3.18E-14 |
| Collagen chain trimerization | 1.16E-11 | ||
| Syndecan-1-mediated signalling events | 2.87E-10 | ||
| Collagen biosynthesis and modifying enzymes | 1.12E-09 | ||
| β1 integrin cell surface interactions | 1.56E-08 | ||
| Focal adhesion-PI3K-Akt-mTOR-signalling pathway | 4.57E-08 | ||
| PDGFR-β signalling pathway | 4.91E-07 | ||
| ECM organization | 1.21E-06 | ||
| Protein alkylation leading to liver fibrosis | 9.21E-06 | ||
| 9 | 29 + 381 + 543 | Integrins in angiogenesis | 6.22E-13 |
| Collagen chain trimerization | 1.13E-10 | ||
| Syndecan-1-mediated signalling events | 2.19E-09 | ||
| Collagen biosynthesis and modifying enzymes | 1.02E-08 | ||
| β1 integrin cell surface interactions | 1.13E-07 | ||
| Mesodermal commitment pathway | 4.32E-07 | ||
| Focal adhesion-PI3K-Akt-mTOR-signalling pathway | 1.08E-06 | ||
| PDGFR-β signalling pathway | 3.94E-06 | ||
| Signalling regulating pluripotency of stem cells | 8.83E-06 | ||
| 10 | 107 + 155 + 381 + 543 | Mesodermal commitment pathway | 3.50E-07 |
| (serve as neutral reference) | PDGFR-β signalling pathway | 4.79E-06 | |