Fig. 1.
The peptide-derived home-protac molecule MSDc, its nano-engineering strategy, and anti-tumor mechanism. The peptide is composed of two MDM2 affinity peptides, which can simultaneously bind to two MDM2 proteins and cause their subsequently mutual ubiquitination and degradation. The corresponding nano-engineered particle MSDNc relies on the self-assembly of [Au(I)-S-MP]n. MSDNc reverses the p53 level in tumor tissues through the MDM2 degradation pathway, and synergistically enhances the anti-tumor effect of anti-pd1 immunotherapy.