Table 2.
Evidence for the role of shortlisted differentially regulated genes on the metastatic progression of various cancer types
| Protein (Expression status) | Cancer type | Observation | Reference |
|---|---|---|---|
| MAP4K4 (Upregulated in cancer) | Hepatocellular carcinoma | EMT, migration to lungs, proliferation, invasion, activate JNK, NF-κβ pathway | [233] |
| Cervical cancer | Induces autophagy by inhibiting PI3K-AKT-mTOR pathway and activate MAPK/ERK pathway | [234] | |
| B cell lymphoma | Prevent apoptosis, induces EMT | [279] | |
| Pancreatic cancer (PDAC) | Cell proliferation | [280] | |
| SPTBN1 (Upregulated in cancer) | Breast cancer | Prevent EMT and breast cancer proliferation | [251] |
| Hepatocellular carcinoma | Activates Wnt signaling and promotes stem cell like features | [252] | |
| Ovarian cancer | SPTBN1 activates the JAK/STAT3 and mesenchymal transformation | [249] | |
| Cervical cancer | SPTBN1 activates TGF-β/ Smad pathway to exert anti-tumor effect | [250] | |
| PCDH7 (Downregulated in cancer) | Cervical cancer | Down regulated in cervical cancer contributes to migration and invasion | [278] |
| Gastric cancer | Cell migration and invasion is inhibited through E-cadherin | [277] | |
| KLK8 (Upregulated in cancer) | Cervical cancer | Immunohistochemistry staining conformed TADG-14 overexpression in cervical cancer specimens | [254] |
| Colorectal cancer | Promote EMT and CRC progression effect is mediated PAR1-dependent pathway | [256] | |
| Cervical cancer | KLK8 expression is correlated with the precancerous and cancerous stages of HPV infection | [281] | |
| KLK7 (Upregulated in cancer) | Cervical cancer | Correlated lymph node metastasis, and stromal invasion | [260] |
| Melanoma | Switch from proliferative to invasive phenotype, downregulation of cell adhesion molecules, homotypic cell adhesion and interaction with the extracellular matrix | [282] | |
| Prostate cancer | Promotes invasion and metastasis through inducing EMT | [283] | |
| KLK10 (Downregulated in cancer) | Cervical cancer | miR-199 b-5p on promoting cervical cancer progression by inhibiting KLK10 expression | [284] |
| Prostate cancer | Downregulation of Bcl-2 promotes apoptosis | [285] | |
| SAM68 (Upregulated in cancer) | Cervical cancer | EMT, pelvic lymph node metastasis in cervical cancer patients | [244] |
| Breast cancer | Lymph node metastasis and cancer progression | [286] |