Fig. 6.

Immunohistochemical staining on day 12 after treatment (A, n = 5). Quantification of positive cell numbers of Bcl-2 (B), Bax (C), and (D) Caspase-3. The arrows represent Bcl-2, Bax, and caspase-3 positive cells (brown color, × 400 magnification). DOX; Doxorubicin, Api; Apigenin, Api-AuNPs; Apigenin coated gold nanoparticles. Data are presented as Mean ± SEM. *P < 0.05, **P < 0.01 and ***P < 0.001 vs. Ctrl group, ##P < 0.01 and ###P < 0.001 vs. DOX group and $$ P < 0.01 and $$$ P < 0.001 vs. Api + DOX group. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)