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. Author manuscript; available in PMC: 2023 Mar 11.
Published in final edited form as: Nat Rev Neurol. 2011 Apr 12;7(5):263–272. doi: 10.1038/nrneurol.2011.43

Figure 1 |.

Figure 1 |

The distinct histological lesions of CBD and PSP visualized with tau immunohistochemistry. a | The astrocytic plaque is a hallmark of CBD. b | Tufted astrocytes are found in the superior frontal cortex of patients with PSP. c | Numerous neuropil threads in the internal capsule are found in patients with CBD; d | by contrast, those with PSP have sparse neuropil threads with oligodendroglial coiled bodies. e | Western blot of detergent-insoluble tau proteins (P3 fraction) from patients with CBD and PSP. The CBD and PSP samples both exhibit the characteristic major doublet of hyperphosphorylated full-length tau at 64 kDa and 68 kDa (asterisk). Cleaved tau fragments from a patient with CBD migrate as two bands at approximately 37 kDa (small arrow), whereas cleaved fragments from a patient with PSP migrate as a single band at 33 kDa (large arrow). Abbreviations: CBD, corticobasal degeneration; PSP, progressive supranuclear palsy.