Figure 4.

TEX41 affected lung adenocarcinoma (LUAD) cell migration, invasion and metastasis via Runx2. A. Runx2 expression in primary LUAD. B. Runx2 expression in LUAD bone metastasis (BM). C, D. Runx2 was highly expressed in LUAD cell lines. E, F. TEX41 interference inhibited Runx2 mRNA and protein expressions. G, H. TEX41 overexpression upregulated Runx2 mRNA and protein expressions. I. Fluorescence in-situ hybridization showed that TEX41 and Runx2 colocalized in the nucleus. J-L. TEX41 affected LUAD cell migration, invasion and metastasis via Runx2. *P<0.05, **P<0.01, ***P<0.001.