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. 2023 Mar 11;18:51. doi: 10.1186/s13014-023-02241-4

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Integration of global mRNA expression data with scores of inherent therapy resistance in human glioblastoma cell lines. a Graphical representation of genes whose log2 mRNA expression levels show strong positive or negative correlation (|R|≥ 0.9) with inherent resistance to single-shot RTX, fractionated RTX, TMZ, and single-shot RTX + TMZ in human glioblastoma cell lines. Only genes with an average log2 expression value of 6 or higher compared to astrocytes are shown. b Intersect analysis of genes whose log2 mRNA expression shows significant positive or negative correlation (|R|≥ 0.9) with inherent resistance to single-shot RTX (blue), fractionated RTX (red), TMZ (green), and single-shot RTX + TMZ (yellow)