Fig. 5.

Gene set enrichment analysis (GSEA) on the basis of genes correlating with therapy resistance identifies pathways of potential contribution to therapy resistance in human glioblastoma cell lines. a Tabular presentation of pre-ranked gene set enrichment analysis (GSEA) results on the basis of obtained correlation coefficients (therapy resistance scores vs. gene expression data), and the MSigDB hallmarks collection [9] (FDR q-value cut-off ≤ 0.1). Positively enriched hallmark gene sets are depicted in pink, and negatively enriched hallmark gene sets are depicted in blue. b, c Correlation analysis of gene set variation indices as determined by gene set variation analysis (GSVA), and therapy resistance scores to fractionated RTX, single-shot RTX + TMZ, and sole TMZ