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. 2023 Feb 15;12(2):321–339. doi: 10.21037/tcr-22-2036

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2023 Translational Cancer Research. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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Schematic diagram of the ECM-related prognostic signature construction and characterization. (A) The differentially expressed ECM genes were identified in CC through differential expression analysis. (B) ECM-related gene signature was constructed using training cohort. (C) ECM-related risk model was validated in various validation cohorts. (D) A new nomogram was constructed and validated. (E) Immune cell infiltration was analyzed. (F) Protein expression validation using Human Protein Atlas. TCGA, The Cancer Genome Atlas; COAD, colon adenocarcinoma; ECM, extracellular matrix; DEG, differentially expressed gene; KEGG, Kyoto Encyclopedia of Genes and Genomes; GO, gene ontology; Lasso, least absolute shrinkage and selection operator; KM, Kaplan-Meier survival analysis; ROC, receiver-operating characteristic.