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. 2023 Feb 15;12(2):321–339. doi: 10.21037/tcr-22-2036

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2023 Translational Cancer Research. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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Functional enrichment analysis of the identified differentially expressed ECM-related genes in TCGA-COAD cohort. (A) Volcano plot of identified differentially expressed ECM-related genes. Green dots represent 105 downregulated genes; red dots represent 89 upregulated genes. Venn diagram shows the intersection of differentially expressed genes and ECM-related genes. (B) Heatmap of identified differentially expressed ECM-related genes. Green represents downregulation, and red represents upregulation of genes. (C) Top 10 enriched KEGG pathways terms of differentially expressed ECM-related genes. (D-F) Top 10 enriched biological processes, molecular functions, cellular components terms of differentially expressed ECM-related genes. ECM, extracellular matrix; TCGA, The Cancer Genome Atlas; COAD, colon adenocarcinoma; KEGG, Kyoto Encyclopedia of Genes and Genomes; GO, gene ontology. BP, biological process; CC, cellular Component; MF, molecular function.