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. 2023 Feb 15;12(2):321–339. doi: 10.21037/tcr-22-2036

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2023 Translational Cancer Research. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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Construction and verification of nomogram. (A) Univariate Cox regression analysis in training cohort. (B) Multivariate Cox regression analysis in training cohort. (C) The prognostic nomogram constructed based on the risk score of ECM-based signature and clinical factors predicted the overall survival rate of COAD patients at 1-, 3-, and 5-year. (D) Time-dependent ROC curves for the prognostic performance of the nomogram in COAD cohort. (E) Time-dependent calibration curves show the concordance between predicted and observed 1-, 3-, and 5-year survival rates. ECM, extracellular matrix; COAD, colon adenocarcinoma; ROC, receiver-operating characteristic; HR, hazard ratio; 95% CI, 95% confidence interval; AJCC, American Joint Committee on Cancer; T stage, Tumor stage; N stage, Nodal Involvement stage; M stage, Metastasis stage; AUC, area under the curve.