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. Author manuscript; available in PMC: 2023 Mar 11.
Published in final edited form as: Nat Genet. 2020 Jul 20;52(8):790–799. doi: 10.1038/s41588-020-0664-8

Extended Data Fig. 9: Prostate cancer and breast cancer risk heritability attributable to germline variation within prostate tumor chromatin states.

Extended Data Fig. 9:

(a) Prostate cancer heritability attributable to each prostate cancer chromHMM state. (b) Breast cancer heritability attributable to each prostate cancer chromHMM state. %SNPs: percentage of single nucleotide polymorphisms residing within a chromatin state; %h2: proportion of prostate cancer risk heritability; se: standard error; Enrichment: heritability based on overall proportion of SNPs within the chromatin state. ( c) Q-Q Plot of PCa risk GWAS statistics in lineage specific and non-specific features. Lineage specific promoters, enhancers, and all other variants shown in green, orange, and black respectively. Variants with Chi-squared statistic > 80 were removed, as recommend by LD-score regression to mitigate outliers. Across all variants, mean Chi-squared statistic was 1.6 (s.e. 0.04), 1.7 (s.e. 0.07), and 1.2 (s.e. 0.003) for variants in promoters, enhancers, and all variants.