Table 1 |.
Specimens included in the study by tissue and epigenetic mark
AR | FOXA1 | HOXB13 | H3K27ac | H3K4me2 | H3K4me3 | H3K27me3 | ATAC | All marks | |
---|---|---|---|---|---|---|---|---|---|
Total | 59 | 42 | 42 | 86 | 8 | 10 | 11 | 10 | 268 |
Normal prostate epithelium | 13* | 14 | 14 | 37+ | 4 | 3 | 4 | 4 | 93 |
Primary prostate tumor | 31* | 13 | 13 | 32 | 4 | 7 | 7 | 6 | 113 |
mCRPC† | 15 | 15 | 15 | 17 | 0 | 0 | 0 | 0 | 62 |
Median no. peaks (range) | 20,619 (1,577–73,723) | 37,691 (3,174 – 99,041) | 47,338 (1,709 – 90,075) | 34,609 (2,337 – 127,042) | 69,558 (41,095 – 83,869) | 33,215 (28,952 – 38,447) | 254,148 (112,809 – 316,413) | 48,139 (25,324 – 60,232) |
Includes seven normal prostate and 13 primary tumor AR ChIP libraries published previously6.
Includes H3K27ac ChIP-seq performed in a specimen derived from human fetal urogenital sinus20.
ChIP-seq experiments performed using PDXs derived from human mCRPC with the exception of two H3K27ac ChIP-seq specimens derived from patient mCRPC liver biopsies.