Table 3. Age-standardized trends of the liver cancer mortality rates in the U.S., 1975 to 2017.

Mortality	Trend 1			Trend 2			Trend 3			Trend 4			Trend 5			Trend 6			AAPC
	Years	APC		Years	APC		Years	APC		Years	APC		Years	APC		Years	APC		1975–2017
Overall	1975–1980	0.17		1980–1987	1.99*		1987–1995	3.75*		1995–2007	1.89*		2007–2013	3.17*		2013–2017	0.65		2.41*
Gender
Male	1975–1985	1.50*		1985–1996	3.78*		1996–1999	0.31		1999–2013	2.66*		2013–2017	0.58					2.51*
Female	1975–1984	0.23		1984–1995	3.13*		1995–2008	1.17*		2008–2013	3.25*		2013–2017	1.32*					1.92*
Race
White	1975–1978	−1.23		1978–1987	1.65*		1987–1996	3.90*		1996–2000	0.54		2000–2013	2.78*		2013–2017	1.40*		2.48*
Black	1975–1988	0.77*		1988–1995	3.19*		1995–2000	0.29		2000–2013	2.49*		2013–2017	0.11					1.84*

The trends were analyzed using the Joinpoint Regression Program (version 4.8), allowing up to 5 joinpoints. *, the APC or AAPC is significantly different from zero (P<0.05). AAPC, average annual percent change; APC, annual percent change based on mortality rates age adjusted to the standard population.