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. 2023 Mar 7;18:1131–1143. doi: 10.2147/IJN.S400798

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© 2023 Zhang et al.

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Effect of ES NPs-HA on the excitability of DRG neurons in SNL mice. The number of Aps in DRG neurons of mice receiving ES NPs-HA treatment was recorded, 5 days after SNL (A); The representative traces of action potentials in responding to 100, 200, and 300 pA ramp current stimulation (B–E). Sham (B); SNL (C); SNL+NC NPs-HA (D); SNL+ES NPs-HA (E). **P<0.01, ***P<0.001, vs SNL+NC Ps-HA; ^###P<0.001, vs Sham. Two-way RM ANOVA followed by the Bonferroni test. Sham: Sham surgery group; SNL: Spinal nerve ligation group; SNL+NC NPs-HA: Injection of hydrogel-containing 0.9% saline-encapsulated nanoparticles after SNL; SNL+ES NPs-HA: Injection of hydrogel-containing esketamine-encapsulated nanoparticles after SNL.