Table 3.
Frequency and Incidence of AECOPDa (Any, Moderate and Severe) During Follow-Up in All Patients (N = 20,212) and Patients Categorized According to Whether They Had at Least One Respiratory Eventb During Baseline (N = 955) or Not (N = 19,257)
| Patients with ≥ 1 AECOPD, n (%) | Total Number of Events | Patient-Years of Follow-Up | Incidence Rate of AECOPD per Patient-Year (95% CI) | |
|---|---|---|---|---|
| AECOPD of any severity | ||||
| All patients | 4839 (23.9) | 8269 | 68,611 | 0.121 (0.118–0.123) |
| No respiratory event at baseline | 4427 (23.0) | 7490 | 66,105 | 0.113 (0.111–0.116) |
| 1+ respiratory event at baseline | 412 (43.1) | 779 | 2506 | 0.311 (0.290–0.333) |
| Moderate AECOPD | ||||
| All patients | 4004 (19.8) | 6313 | 68,611 | 0.092 (0.090–0.094) |
| No respiratory event at baseline | 3804 (19.8) | 6032 | 66,105 | 0.091 (0.089–0.094) |
| 1+ respiratory event at baseline | 200 (20.9) | 281 | 2506 | 0.112 (0.100–0.126) |
| Severe AECOPD | ||||
| All patients | 1301 (6.4) | 1956 | 68,611 | 0.029 (0.027–0.030) |
| No respiratory event at baseline | 1007 (5.2) | 1458 | 66,105 | 0.022 (0.021–0.023) |
| 1+ respiratory event at baseline | 294 (30.8) | 498 | 2506 | 0.199 (0.182–0.217) |
Notes: aAECOPD during follow-up were defined as moderate (managed in the outpatient setting) or severe (defined as hospitalization for COPD exacerbation, lower respiratory tract infection or acute respiratory failure); bRespiratory events during baseline included lower respiratory tract infection and acute respiratory failure.
Abbreviations: AECOPD, acute exacerbation of chronic obstructive pulmonary disease; CI, confidence interval; COPD, chronic obstructive pulmonary disease.