Figure 10.

At day 14 following repeated stress (when mice typically return to baseline withdrawal thresholds), spare respiratory capacity and ATP production are increased in female mice. A, B, Mitochondrial OCRs were measured for females (A) and males (B) from which several metabolic parameters were calculated. C, D, Female mice exhibited increased mitochondrial spare respiratory capacity (C) and ATP production (D) in their TGs, an effect that was not observed in male mice, suggesting a potential sex difference in the long-term effects of stress on mitochondrial function (n = 3 replicate runs). Data are represented as the mean ± SEM. ****p < 0.0001.