Figure 11.

Administration of low-dose SNP induces robust changes in mitochondrial function in the TGs of male, but not female mice, an effect that is attenuated by pretreatment with FeTMPyP. Fourteen days following repeated stress, mice were administered either FeTMPyP (30 mg/kg, i.p.) or vehicle and were primed with SNP (0.1 mg/kg, i.p.). A, B, Mitochondrial OCRs were measured for females (A) and males (B) from which several metabolic parameters were calculated. C–E, Interestingly, stress-primed male mice exhibited robust increases in maximal respiration (C), spare respiratory capacity (D), and nonmitochondrial respiration (E) in response to SNP. Notably, these changes were attenuated by pretreatment with FeTMPyP. No changes were observed in female mice (n = 3 replicate runs). Data are represented as the mean ± SEM. **p < 0.01, ***p < 0.001, ***p < 0.0001.