Figure 6.

PN mediates stress-induced increases in 3-NT expression in the TGs and dura. A, B, Approximately 24 h following the final day of repeated stress, an increase in 3-NT expression, a marker for PN, was observed in the TGs and dura of female (A) and male (B) mice compared with controls, suggesting an increase in PN activity. These changes were prevented by the administration of FeTMPyP (30 mg/kg) at 1 h poststress, as indicated by a one-way ANOVA with post hoc Bonferroni’s correction (n = 4 independent replicates/group). Representative Western blots are shown. Data are represented as the mean ± SEM. **p < 0.01, ****p < 0.0001.