Table 2.
AP Membrane properties of the different treatment groups
| Vehicle | SIN-1 | SIN-1 + MnTBAP | SIN-1 + FeTPPS | MnTBAP only | ANOVA | |
|---|---|---|---|---|---|---|
| Capacitance (pF) | 25.82 ± 0.94 | 25 ± 0.66 | 25.73 ± 1.13 | 26.78 ± 1.15 | 23.17 ± 1.15 |
F(4,73) = 1.387, p = 0.25 |
| RMP (mV) | −53.2 ± 0.96 | −50.1 ± 1.39 | −51.1 ± 1.72 | −52.6 ± 2.22 | −52.4 ± 1.41 |
F(4,73) = 0.9081, p = 0.46 |
| AP threshold (mV) | −18.09 ± 0.95 | −22.53 ± 0.63* | −19.12 ± 0.89 | −20.92 ± 1.03 | −17.69 ± 1.27 |
F(4,71) = 4.957, p = 0.0014; *p = 0.0012 |
| AP amplitude (mV) | 77.58 ± 1.24 | 82.31 ± 0.52* | 77.35 ± 1.1 | 80.38 ± 1.28 | 75.81 ± 1.52 |
F(4,71) = 5.241, p = 0.0009; *p = 0.005 |
| AP half-width (ms) | 3.19 ± 0.13 | 3.6 ± 0.1 | 3.17 ± 0.13 | 5.26 ± 0.38* | 3.38 ± 0.16 |
F(4,71) = 19.05, p < 0.0001; *p < 0.0001 |
| Rheobase (pA) | 301.36 ± 15.81 | 220 ± 9.85* | 288.57 ± 13.86 | 275.56 ± 11.68 | 275 ± 10.84 |
F(4,71) = 6.319, p = 0.0002; *p < 0.0001 |
| Input resistance (MΩ) | 1168.8 ± 85.1 | 1193 ± 69.57 | 1137.19 ± 137.8 | 1203.4 ± 59.58 | 1015.38 ± 116.05 |
F(4,68) = 0.4791, p = 0.751 |
One-way ANOVA followed by post hoc Dunnett's test. Data are represented as mean ± SEM. Asterisks denote a significant difference between the marked group and all other groups, with p-values being reported in the far right column for each row.