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. 2023 Feb 27;10:rbad014. doi: 10.1093/rb/rbad014

Figure 6.

Figure 6.

In vivo anti-tumor metastasis, pharmacokinetics and biodistribution. (a) Illustration of cancer cell inoculation, drug treatment and evaluation of tumor metastasis therapy in mice. (b) H&E staining photos of lung tissue sections and (c) metastatic nodules on each lung of mice after different treatments (n = 4 ∼ 5). (d) Body weight of mice in each group (n = 5). (e) The concentration of ATRA in the plasma of mice after different treatments (n = 4). (f) Biodistribution of ATRA-NPs in mice after 4 and 24 h of administration (n = 4). (g) Western blot images and (h) relative expression values of PIN1, EMT marker proteins and signaling pathway proteins in lung tissue of mice after different treatments (n = 3).