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. 2023 Mar 10;11(3):e005583. doi: 10.1136/jitc-2022-005583

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© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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Anti-VEGF treatment enhances function of CAR-T cells and effector T cells in GBM. (A) GSC005 tumors were treated as shown in the schematic. (B) Percentage of IL2+and IFN-γ+ CAR T cells inside the GSC005 GBM tumors. (C) Percentage of CD4+T cells, CD8+T cells, and the cytotoxic Granzyme B+TNF-α+ CD8+ T cells in the GSC005 tumors. Error bars show ±SEM. Statistical analysis was performed using Student’s t-test. *p<0.05, **p<0.01, ***p<0.001. CAR, chimeric antigen receptor; VEGF, vascular endothelial growth factor.