Table 2. Presence of niche and virulence factors of Corynebacterium in C. silvaticum strains from Portugal.
| Type | Gene | Product | Presence | Reference locus tag | Reference species | Reference |
|---|---|---|---|---|---|---|
| Niche | – | C. diphtheriae DIP0733 homolog | Yes | CULC22_00609 | Cul | Tauch & Burkovski (2015) |
| Niche | – | Secreted subtilisin-like serine protease | Yes | cpfrc_00397 | Cp | Trost et al. (2010) |
| Niche | – | Secreted subtilisin-like serine protease | Yes, except in PO25/4 | cpfrc_01634 | Cp | Trost et al. (2010) |
| Niche | – | Secreted trypsin-like serine protease | No | cpfrc_00562 | Cp | Trost et al. (2010) |
| Niche | – | Secreted SGNH-hydrolase | Yes | cpfrc_00536 | Cp | Trost et al. (2010) |
| Niche | – | Trypsin-like serine protease | Yes | FIT55_05760, A0A5C5F2T7 | Cs | Möller et al. (2020b) |
| Niche | accD3 | Acyl-CoA carboxylase b-subunit involved in mycolic acid synthesis | Yes | cpfrc_01953 | Cp | Trost et al. (2010) |
| Niche | asa | Ceramidase | No | jk1103 | Cj | Tauch et al. (2005), Tauch & Burkovski (2015) |
| Niche | che | Cholesterol esterase | No | jk2054 | Cj | Tauch et al. (2005), Tauch & Burkovski (2015) |
| Niche | choE | Cholesterol oxidase | No | jk0629 | Cj | Tauch et al. (2005), Tauch & Burkovski (2015) |
| Niche | cwlH | Cell wall-associated hydrolase | Yes | CULC809_01521 | Cul | Trost et al. (2011); Tauch & Burkovski (2015) |
| Niche | dtsR1 | Acetyl-CoA carboxylase b-subunit involved in fatty acid synthesis | Yes | cpfrc_00492 | Cp | Trost et al. (2010) |
| Niche | dtsR2 | Acyl-CoA carboxylase b-subunit involved in mycolic acid synthesis | Yes | cpfrc_00491 | Cp | Trost et al. (2010) |
| Niche | endoE | Endoglycosidase E (former corynebacterial protease CP40) | Yes | CULC809_01974 | Cul | Trost et al. (2011) |
| Niche | mdbA | Thiol-disulfide oxidoreductase | Yes | DIP1880 | Cd | Reardon-Robinson et al. (2015), Tauch & Burkovski (2015) |
| Niche | nanH | Sialidase (neuraminidase H) | Yes | CULC809_00434 | Cul | Trost et al. (2011) |
| Niche | nor | Nitric oxide reductase | No | cpfrc_00128 | Cp | Trost et al. (2010) |
| Niche | nrpS1 | Nonribosomal peptide synthetase 1 | Yes | cpfrc_00565 | Cp | Trost et al. (2010) |
| Niche | nrpS2 | Nonribosomal peptide synthetase 2 | No | cpfrc_00180 | Cp | Trost et al. (2010) |
| Niche | rhuM | RhuM-like protein | No | CulFRC58_0285 | Cul | Trost et al. (2011); Weerasekera et al. (2019) |
| Niche | rpfA | Resuscitation-promoting factor A (muralytic enzyme) | Yes | cpfrc_00594 | Cp | Trost et al. (2010) |
| Niche | rpfB | Resuscitation-promoting factor B (muralytic enzyme) | Yes | cpfrc_00679 | Cp | Trost et al. (2010) |
| Niche | rpfI | Resuscitation-promoting factor-interacting protein | Yes | CULC809_01133 | Cul | Trost et al. (2011); Tauch & Burkovski (2015) |
| Niche | spaB | Surface-anchored protein (minor pilus subunit) | Yes | CULC809_01980 | Cul | Trost et al. (2011); Tauch & Burkovski (2015) |
| Niche | spaC | Surface-anchored protein (tip pilus protein) | Pseudogene, no CWSS | CULC809_01979 | Cul | Trost et al. (2011); Tauch & Burkovski (2015) |
| Niche | spaD | Surface-anchored protein (major pilus subunit) | Pseudogene, no CWSS | CULC809_01952 | Cul | Trost et al. (2011); Tauch & Burkovski (2015) |
| Niche | spaE | Surface-anchored protein (minor pilus subunit) | Pseudogene, no SP | CULC809_01950 | Cul | Trost et al. (2011); Tauch & Burkovski (2015) |
| Niche | spaF | Surface-anchored protein (tip pilus protein) | Pseudogene, no SP | CULC809_01949 | Cul | Trost et al. (2011); Tauch & Burkovski (2015) |
| Niche | srtA | Sortase A | Yes | CULC809_01981 | Cul | Trost et al. (2011); Tauch & Burkovski (2015) |
| Niche | srtB | Sortase B | Yes | CULC809_01953 | Cul | Trost et al. (2011); Tauch & Burkovski (2015) |
| Niche | srtC | Sortase C | Yes | CULC809_01951 | Cul | Trost et al. (2011); Tauch & Burkovski (2015) |
| Niche | tspA | Trypsin-like serine protease | No | CULC809_01848 | Cul | Trost et al. (2011) |
| Niche | vsp1 | Venom serine protease | Yes | CULC809_00509 | Cul | Trost et al. (2011) |
| Niche | vsp2 | Venom serine protease | Yes | CULC809_01964 | Cul | Trost et al. (2011) |
| Virulence | pld | Phospholipase D | Yes | ET810_03855 | Cs | Trost et al. (2011); Tauch & Burkovski (2015) |
| Virulence | rbp | Shiga-like ribosome-binding protein | No | CULC809_00177 | Cul | Trost et al. (2011); Tauch & Burkovski (2015) |
| Virulence | tox | Diphtheria toxin | Yes | DIP0222 | Cd | Tauch & Burkovski (2015) |
| Virulence | relA | Guanosine-3′, 5′-bis(diphosphate) 3′-pyrophosphohydrolase / GTP pyrophosphokinase, (p)ppGpp synthetase II | Yes | – | – | Abricate |
| Virulence | ideR | Iron-dependent repressor IdeR/DtxR | Yes | – | – | Abricate |
| Virulence | ureB | Urease alpha subunit | Yes | – | – | Abricate |
| Resistance | rpoB2 | Rifampin-resistant beta-subunit of RNA polymerase | Yes | – | – | Abricate |
| Resistance | mtrA | Two component system response regulator MtrA | Yes | – | – | Abricate |
| Resistance | rbpA | RNA-polymerase binding protein which confers resistance to rifampin | Yes | – | – | Abricate |
Notes.
- CWSS
- cell wall sorting signal
- SP
- signal peptide