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. 2023 Mar 8;13(3):e069465. doi: 10.1136/bmjopen-2022-069465

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© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Dose–response relationship curves. Adjusted OR of events and MACE at 3 months and 12 months according to LDL-C at baseline in patients: (A) stroke at 3 months; (B) ischaemic stroke at 3 months; (C) haemorrhagic stroke at 3 months; (D) MACE at 3 months; (E) stroke at 12 months; (F) ischaemic stroke at 12 months; (G) haemorrhagic stroke at 12 months; (H) MACE at 12 months. The full line indicates the adjusted HR and the dashed lines the 95% CI bands. Reference is LDL-C >2.6 mmol/L. Data were fitted using a logistic regression model of restricted cubic spline with three knots (the 5th, 50th, 90th percentiles) for LDL-C level, adjusting for potential covariates. LDL-C, low-density lipoprotein cholesterol; MACE, major adverse cardiovascular events.