Table 2.
Association between baseline LDL-C levels and outcomes at 3 months and 12 months
| Total | Events (n%) | HR (95% CI) unadjusted | P value | HR (95% CI) adjusted | P value | |
| 3 months | ||||||
| Stroke recurrence | ||||||
| LDL ≤1.4 mmol/L | 1407 | 69 (4.9) | 0.72 (0.55 to 0.94) | 0.01 | 0.74 (0.57 to 0.97) | 0.03 |
| 1.4<LDL≤1.8 mmol/L | 1636 | 95 (5.8) | 0.85 (0.68 to 1.08) | 0.18 | 0.89 (0.70 to 1.12) | 0.32 |
| 1.8<LDL≤2.6 mmol/L | 3655 | 219 (6.0) | 0.88 (0.74 to 1.05) | 0.17 | 0.91 (0.76 to 1.08) | 0.28 |
| LDL >2.6 mmol/L | 4040 | 273 (6.8) | Reference | – | Reference | – |
| Ischaemic stroke | ||||||
| LDL ≤1.4 mmol/L | 1407 | 65 (4.6) | 0.72 (0.55 to 0.95) | 0.02 | 0.74 (0.56 to 0.98) | 0.03 |
| 1.4<LDL≤1.8 mmol/L | 1636 | 88 (5.4) | 0.84 (0.66 to 1.07) | 0.16 | 0.87 (0.68 to 1.11) | 0.27 |
| 1.8<LDL≤2.6 mmol/L | 3655 | 201 (5.5) | 0.86 (0.72 to 1.04) | 0.11 | 0.89 (0.74 to 1.07) | 0.22 |
| LDL >2.6 mmol/L | 4040 | 257 (6.4) | Reference | – | Reference | – |
| Haemorrhagic stroke | ||||||
| LDL ≤1.4 mmol/L | 1407 | 4 (0.3) | 0.52 (0.18 to 1.51) | 0.23 | 0.55 (0.19 to 1.61) | 0.28 |
| 1.4<LDL≤1.8 mmol/L | 1636 | 9 (0.6) | 1.01 (0.46 to 2.19) | 0.98 | 1.03 (0.47 to 2.26) | 0.93 |
| 1.8<LDL≤2.6 mmol/L | 3655 | 20 (0.6) | 1.00 (0.55 to 1.84) | 0.99 | 0.93 (0.50 to 1.73) | 0.82 |
| LDL >2.6 mmol/L | 4040 | 22 (0.5) | Reference | – | Reference | – |
| MACE | ||||||
| LDL ≤1.4 mmol/L | 1407 | 71 (5.1) | 0.72 (0.56 to 0.94) | 0.01 | 0.75 (0.57 to 0.97) | 0.03 |
| 1.4<LDL≤1.8 mmol/L | 1636 | 100 (6.1) | 0.88 (0.70 to 1.10) | 0.27 | 0.91 (0.72 to 1.15) | 0.42 |
| 1.8<LDL≤2.6 mmol/L | 3655 | 231 (6.3) | 0.91 (0.77 to 1.08) | 0.29 | 0.93 (0.78 to 1.11) | 0.43 |
| LDL >2.6 mmol/L | 4040 | 279 (6.9) | Reference | – | Reference | – |
| 12 months | ||||||
| Stroke recurrence | ||||||
| LDL ≤1.4 mmol/L | 1407 | 114 (8.1) | 0.76 (0.62 to 0.93) | 0.009 | 0.77 (0.62 to 0.95) | 0.01 |
| 1.4<LDL≤1.8 mmol/L | 1636 | 158 (9.7) | 0.91 (0.76 to 1.08) | 0.30 | 0.92 (0.76 to 1.10) | 0.36 |
| 1.8<LDL≤2.6 mmol/L | 3655 | 339 (9.7) | 0.87 (0.76 to 1.01) | 0.06 | 0.89 (0.77 to 1.03) | 0.12 |
| LDL >2.6 mmol/L | 4040 | 426 (10.5) | Reference | – | Reference | – |
| Ischaemic stroke | ||||||
| LDL ≤1.4 mmol/L | 1407 | 102 (7.6) | 0.72 (0.58 to 0.90) | 0.004 | 0.73 (0.59 to 0.91) | 0.005 |
| 1.4<LDL≤1.8 mmol/L | 1636 | 145 (8.9) | 0.89 (0.73 to 1.07) | 0.22 | 0.90 (0.74 to 1.09) | 0.27 |
| 1.8<LDL≤2.6 mmol/L | 3655 | 304 (8.3) | 0.83 (0.72 to 0.97) | 0.02 | 0.86 (0.74 to 1.00) | 0.04 |
| LDL >2.6 mmol/L | 4040 | 400 (9.9) | Reference | – | Reference | – |
| Haemorrhagic stroke | ||||||
| LDL ≤1.4 mmol/L | 1407 | 12 (0.9) | 0.96 (0.50 to 1.84) | 0.89 | 0.97 (0.50 to 1.88) | 0.93 |
| 1.4<LDL≤1.8 mmol/L | 1636 | 15 (0.9) | 1.03 (0.56 to 1.87) | 0.94 | 1.02 (0.56 to 1.88) | 0.95 |
| 1.8<LDL≤2.6 mmol/L | 3655 | 37 (1.0) | 1.13 (0.72 to 1.80) | 0.59 | 1.10 (0.69 to 1.75) | 0.69 |
| LDL >2.6 mmol/L | 4040 | 36 (0.9) | Reference | – | Reference | – |
| MACE | ||||||
| LDL≤1.4 mmol/L | 1407 | 119 (8.5) | 0.76 (0.62 to 0.93) | 0.008 | 0.77 (0.62 to 0.94) | 0.01 |
| 1.4<LDL≤1.8 mmol/L | 1636 | 170 (10.4) | 0.94 (0.79 to 1.12) | 0.47 | 0.94 (0.79 to 1.13) | 0.50 |
| 1.8<LDL≤2.6 mmol/L | 3655 | 363 (9.9) | 0.90 (0.78 to 1.03) | 0.13 | 0.91 (0.79 to 1.05) | 0.20 |
| LDL >2.6 mmol/L | 4040 | 444 (11.0) | Reference | – | Reference | – |
LDL-C, low-density lipoprotein cholesterol; MACE, major adverse cardiovascular events.