Table 4.
Amino acid residues of non-bond interactions between the ligands and receptors
| Drug-receptor complexes | Non-bond interactions | ||
|---|---|---|---|
| Amino acid residues | Bond type | ||
| HB | Others | ||
| DPD-D2 | Ser409 | CHB | – |
| Asp114: | – | Pi-anion | |
| Tyr408 | – | Pi-Pi Stacked | |
| Ile184, Val91, Leu94 | – | Alkyl | |
| Phe189, His393, Tyr408, Trp41, Leu94 | – | Pi-alkyl | |
| PHY-D2 | Thr119 | CHB | – |
| Val115 | CaHB | – | |
| Val91, Leu94, Cys118 | – | Alkyl | |
| Trp100, Phe110, He189, Trp386, Phe389, Phe390, Trp413, Tyr416 | – | Pi-alkyl | |
| ODN-5HT3 | Ile256, Phe254 | CaHB | – |
| Thr257 | Pi-DHB | – | |
| Ile256 | – | Pi-sigma | |
| Ile256, Leu260, | – | Alkyl | |
| Ile256 | – | Pi-alkyl | |
| PHY-5HT3 | Ile93, Val95 | CHB | – |
| Trp94 | CaHB | – | |
| Leu99, Leu129, Val95, Pro113, Ile100, Leu129, Pro110, | – | Alky | |
| Phe103, Phe153 | – | Pi-alkyl | |
HB Hydrogen bond, CHB Conventional hydrogen bond, CaHB Carbon hydrogen bond, Pi-DHB Pi-donor hydrogen bond